What robot are you using? A custom bot or Roli?

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How is it set up? Are you using a H-Bridge? Did you follow any H-Bridge tutorial? Have you checked you have the correct ports set up in the config?

We need a lot more information than you have provided in order to be able to help you.

If it is a H-Bridge, follow my H-Bridge tutorial, it tells you exactly what you need to do if Movement Panel directions don't correspond with actual robot movements.

If your using a modified servo setup, there may be something wrong with your scripting.

If your using an h-bridge and electric motors, please follow the link that Rich posted to his h-bridge tutorial.